Drugmakers Pfizer Inc (PFE-N) and Johnson & Johnson (JNJ-N) decided to end further studies of a closely watched drug, bapineuzumab, aimed to treat Alzheimer’s disease after the treatment failed in a second late-stage clinical trial.

Both companies will discontinue all remaining studies of the drug, including two more late-stage trials and follow-up extension studies, in patients with mild to moderate Alzheimer’s.  The drug is designed to prevent the build-up of amyloid plaque in the brain. Both companies stated that the intravenous bapineuzumab therapy failed to improve cognitive and functional performance compared with placebo in patients who had mild to moderate Alzheimer’s.

As a result, the losses incurred by both companies will have a detrimental effect on third quarter earnings.  See the report outlining which shareholders may be most affected.  Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

 

Best Buy’s founder, Richard Schulze, has offered to take the company private.  Mr. Schulze has offered $24-$26 per share and has talked with the former CEO and COO about coming back.  Any buyout should be a boon for Best Buy’s current investors.  Here are the top 10 active institutional shareholders who would stand to benefit.  Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

Toyota Motor Corp announced outstanding earnings for Q2 2012.  Its Q2 operating profit was the largest quarterly operating profit in four years for the Japanese auto company.  In addition, the company increased its sales target for the remainder of 2012.  Here are the top active institutional shareholders of Toyota, all of which should be positively affected should Toyota outperform for the rest of the year.  Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

General Motors Corp posted better earnings than expected for Q2 2012.

Two main factors driving its success were unusually good results in Europe and delayed spending in the United States.  Some analysts are concerned that GM’s excellent quarter may be an anomaly.  In particular, the delayed spending must be made up in the future, which could affect the bottom line.  Also, as volatility in Europe continues, there is no guarantee GM’s European business will post another successful quarter.  If the outlook on GM declines, GM’s top 10 shareholders could be affected.

See the full report.  Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

 

Apple Inc missed analysts’ expectations for Q2 2012.  The California-based technology company attributed the poor results to lagging iPhone sales ahead of the iPhone 5 rollout later this year, as well as poor sales in Europe.  The list below shows the top 10 active institutional shareholders of Apple Inc. Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

Goldman Sachs Group posted a 12% profit drop for Q2 2012 due to reduced demand for its investment banking services and poor performance from its proprietary investments.  As worries about Europe and the larger economy still loom large, there is no definitive timeframe for Goldman pulling out of its rut.  If performance continues to deteriorate, Goldman’s top shareholders may be affected.   Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

Google’s first female engineer will assume her role today as Yahoo Inc’s CEO.  Marissa will be Yahoo Inc’s third CEO in a year, edging out front-runner and acting CEO Ross Levinsohn. Below is a list of the top 10 active institutional shareholders of Yahoo, all of which could be affected by this change. Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

Nokia announced that it will cut the price of its flagship Lumia 900 smartphone in half.  Many analysts interpret this as another signal that Nokia is losing ground to competition from Apple and Samsung.  Below is a list of the top 10 active institutional shareholders of Nokia, all of which would be affected if Nokia’s prospects continue to decline.  Check out other reports by Thomson Reuters Ownership Intelligence and follow @ownershipintel on Twitter.

 

Thomson Reuters Ownership Intelligence offers free access to industry reports, investor profiles, job movements of investment professionals, and much more. Follow @ownershipintel on Twitter.

Thomson Reuters Ownership Intelligence offers free access to industry reports, investor profiles, job movements of investment professionals, and much more. Follow @ownershipintel on Twitter.